<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03844872</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-12T04:26:23+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Inferring the initiation and development of myeloproliferative neoplasms</title>
            <author role="aut">
              <persName>
                <forename type="first">Gurvan</forename>
                <surname>Hermange</surname>
              </persName>
              <idno type="halauthorid">2304140-0</idno>
              <affiliation ref="#struct-1042590"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alicia</forename>
                <surname>Rakotonirainy</surname>
              </persName>
              <idno type="halauthorid">2635349-0</idno>
              <affiliation ref="#struct-1042590"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mahmoud</forename>
                <surname>Bentriou</surname>
              </persName>
              <idno type="halauthorid">1672620-0</idno>
              <affiliation ref="#struct-1042590"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Amandine</forename>
                <surname>Tisserand</surname>
              </persName>
              <idno type="halauthorid">1568538-0</idno>
              <affiliation ref="#struct-557826"/>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-1049541"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mira</forename>
                <surname>El-Khoury</surname>
              </persName>
              <idno type="idhal" notation="numeric">1183889</idno>
              <idno type="halauthorid" notation="string">2086056-1183889</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2684-9646</idno>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-557826"/>
              <affiliation ref="#struct-1049541"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Girodon</surname>
              </persName>
              <idno type="halauthorid">392351-0</idno>
              <affiliation ref="#struct-300924"/>
              <affiliation ref="#struct-1096458"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Marzac</surname>
              </persName>
              <idno type="halauthorid">601009-0</idno>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-150180"/>
              <affiliation ref="#struct-1049541"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">William</forename>
                <surname>Vainchenker</surname>
              </persName>
              <idno type="idhal" notation="numeric">757193</idno>
              <idno type="halauthorid" notation="string">172462-757193</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4705-202X</idno>
              <idno type="IDREF">https://www.idref.fr/084304685</idno>
              <idno type="VIAF">https://viaf.org/viaf/7522958</idno>
              <idno type="ISNI">http://isni.org/isni/000000000151168X</idno>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-1057805"/>
              <affiliation ref="#struct-1049541"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Plo</surname>
              </persName>
              <email type="md5">6cee02cd6f8983beae7c0db245702ccb</email>
              <email type="domain">gustaveroussy.fr</email>
              <idno type="idhal" notation="string">isabelle-plo</idno>
              <idno type="idhal" notation="numeric">760113</idno>
              <idno type="halauthorid" notation="string">338019-760113</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5915-6910</idno>
              <idno type="IDREF">https://www.idref.fr/068888376</idno>
              <affiliation ref="#struct-156104"/>
              <affiliation ref="#struct-1057805"/>
              <affiliation ref="#struct-1049541"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Paul-Henry</forename>
                <surname>Cournède</surname>
              </persName>
              <email type="md5">7fbd834794a518970b717a9867dca40e</email>
              <email type="domain">centralesupelec.fr</email>
              <idno type="idhal" notation="string">paul-henry-cournede</idno>
              <idno type="idhal" notation="numeric">15896</idno>
              <idno type="halauthorid" notation="string">144626-15896</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7679-6197</idno>
              <idno type="IDREF">https://www.idref.fr/145563073</idno>
              <affiliation ref="#struct-1042590"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Gurvan</forename>
                <surname>Hermange</surname>
              </persName>
              <email type="md5">9b827148148432cae200aee71a229c5e</email>
              <email type="domain">centralesupelec.fr</email>
            </editor>
            <funder ref="#projanr-54797"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-11-09 09:48:20</date>
              <date type="whenModified">2026-05-12 03:19:19</date>
              <date type="whenReleased">2022-11-16 07:38:58</date>
              <date type="whenProduced">2022-09-09</date>
              <date type="whenEndEmbargoed">2022-11-09</date>
              <ref type="file" target="https://centralesupelec.hal.science/hal-03844872v1/document">
                <date notBefore="2022-11-09"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://centralesupelec.hal.science/hal-03844872v1/file/PNAS22.pdf" id="file-3853812-3370129">
                <date notBefore="2022-11-09"/>
              </ref>
              <ref type="annex" n="0" target="https://centralesupelec.hal.science/hal-03844872v1/file/supplemental.pdf" id="file-3853812-3370130">
                <date notBefore="2022-11-15"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1104690">
                <persName>
                  <forename>Gurvan</forename>
                  <surname>Hermange</surname>
                </persName>
                <email type="md5">9b827148148432cae200aee71a229c5e</email>
                <email type="domain">centralesupelec.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03844872</idno>
            <idno type="halUri">https://centralesupelec.hal.science/hal-03844872</idno>
            <idno type="halBibtex">hermange:hal-03844872</idno>
            <idno type="halRefHtml">&lt;i&gt;Proceedings of the National Academy of Sciences of the United States of America&lt;/i&gt;, 2022, 119 (37), &lt;a target="_blank" href="https://dx.doi.org/10.1073/pnas.2120374119"&gt;&amp;#x27E8;10.1073/pnas.2120374119&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (37), &amp;#x27E8;10.1073/pnas.2120374119&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3853812-3370129"/><ref corresp="#file-3853812-3370130"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-BOURGOGNE">Université Bourgogne Europe</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="IGR" corresp="FNCLCC">Institut Gustave Roussy</idno>
            <idno type="stamp" n="CENTRALESUPELEC">Ecole CentraleSupélec</idno>
            <idno type="stamp" n="MICS">Mathématiques et Informatique pour la Complexité et les Systèmes</idno>
            <idno type="stamp" n="TDS-MACS">Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="LNC-UMR866" corresp="UNIV-BOURGOGNE">Lipides Nutrition Cancer - UMR866</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="GS-COMPUTER-SCIENCE">Graduate School Computer Science</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="HUB-IA">Hub Intelligence Artificielle de CentraleSupélec</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="DYNAMO">Dynamique moléculaire de la transformation hématopoïétique </idno>
            <idno type="stamp" n="CSHMYELO">Cellules souches hématopoïétiques et développement des hémopathies myéloïdes </idno>
            <idno type="stamp" n="INSTITUT-AGRO">Institut Agro</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES">Académie des sciences</idno>
            <idno type="stamp" n="CTM_UMR1231" corresp="UNIV-BOURGOGNE">CTM</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES" corresp="ACADEMIE-SCIENCES">Publications des membres, correspondants et associés étrangers de l'Académie des sciences</idno>
            <idno type="stamp" n="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES-1" corresp="ACADEMIE-SCIENCES-PUBLICATIONS-MEMBRES">Publications des membres de l'Académie des sciences (lot 1)</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Inferring the initiation and development of myeloproliferative neoplasms</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Gurvan</forename>
                    <surname>Hermange</surname>
                  </persName>
                  <idno type="halauthorid">2304140-0</idno>
                  <affiliation ref="#struct-1042590"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alicia</forename>
                    <surname>Rakotonirainy</surname>
                  </persName>
                  <idno type="halauthorid">2635349-0</idno>
                  <affiliation ref="#struct-1042590"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mahmoud</forename>
                    <surname>Bentriou</surname>
                  </persName>
                  <idno type="halauthorid">1672620-0</idno>
                  <affiliation ref="#struct-1042590"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Amandine</forename>
                    <surname>Tisserand</surname>
                  </persName>
                  <idno type="halauthorid">1568538-0</idno>
                  <affiliation ref="#struct-557826"/>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-1049541"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mira</forename>
                    <surname>El-Khoury</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1183889</idno>
                  <idno type="halauthorid" notation="string">2086056-1183889</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2684-9646</idno>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-557826"/>
                  <affiliation ref="#struct-1049541"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Girodon</surname>
                  </persName>
                  <idno type="halauthorid">392351-0</idno>
                  <affiliation ref="#struct-300924"/>
                  <affiliation ref="#struct-1096458"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Marzac</surname>
                  </persName>
                  <idno type="halauthorid">601009-0</idno>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-150180"/>
                  <affiliation ref="#struct-1049541"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">William</forename>
                    <surname>Vainchenker</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">757193</idno>
                  <idno type="halauthorid" notation="string">172462-757193</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4705-202X</idno>
                  <idno type="IDREF">https://www.idref.fr/084304685</idno>
                  <idno type="VIAF">https://viaf.org/viaf/7522958</idno>
                  <idno type="ISNI">http://isni.org/isni/000000000151168X</idno>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-1057805"/>
                  <affiliation ref="#struct-1049541"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Plo</surname>
                  </persName>
                  <email type="md5">6cee02cd6f8983beae7c0db245702ccb</email>
                  <email type="domain">gustaveroussy.fr</email>
                  <idno type="idhal" notation="string">isabelle-plo</idno>
                  <idno type="idhal" notation="numeric">760113</idno>
                  <idno type="halauthorid" notation="string">338019-760113</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5915-6910</idno>
                  <idno type="IDREF">https://www.idref.fr/068888376</idno>
                  <affiliation ref="#struct-156104"/>
                  <affiliation ref="#struct-1057805"/>
                  <affiliation ref="#struct-1049541"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul-Henry</forename>
                    <surname>Cournède</surname>
                  </persName>
                  <email type="md5">7fbd834794a518970b717a9867dca40e</email>
                  <email type="domain">centralesupelec.fr</email>
                  <idno type="idhal" notation="string">paul-henry-cournede</idno>
                  <idno type="idhal" notation="numeric">15896</idno>
                  <idno type="halauthorid" notation="string">144626-15896</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7679-6197</idno>
                  <idno type="IDREF">https://www.idref.fr/145563073</idno>
                  <affiliation ref="#struct-1042590"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">7969</idno>
                <idno type="issn">0027-8424</idno>
                <idno type="eissn">1091-6490</idno>
                <title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
                <imprint>
                  <publisher>National Academy of Sciences</publisher>
                  <biblScope unit="volume">119</biblScope>
                  <biblScope unit="issue">37</biblScope>
                  <date type="datePub">2022-09-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1073/pnas.2120374119</idno>
              <idno type="pubmed">36083966</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="info.info-bi">Computer Science [cs]/Bioinformatics [q-bio.QM]</classCode>
              <classCode scheme="halDomain" n="info.info-cc">Computer Science [cs]/Computational Complexity [cs.CC]</classCode>
              <classCode scheme="halDomain" n="info.info-mo">Computer Science [cs]/Modeling and Simulation</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The developmental history of blood cancer begins with mutation acquisition and the resulting malignant clone expansion. The two most prevalent driver mutations found in myeloproliferative neoplasms— JAK2 V617F and CALR m —occur in hematopoietic stem cells, which are highly complex to observe in vivo. To circumvent this difficulty, we propose a method relying on mathematical modeling and statistical inference to determine disease initiation and dynamics. Our findings suggest that CALR m mutations tend to occur later in life than JAK2 V617F . Our results confirm the higher proliferative advantage of the CALR m malignant clone compared to JAK2 V617F . Furthermore, we illustrate how mathematical modeling and Bayesian inference can be used for setting up early screening strategies.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1042590" status="VALID">
          <idno type="IdRef">14797299X</idno>
          <idno type="RNSR">200615286U</idno>
          <idno type="ROR">https://ror.org/03q29s414</idno>
          <orgName>Mathématiques et Informatique pour la Complexité et les Systèmes</orgName>
          <orgName type="acronym">MICS</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Plateau de Moulon 3 rue Joliot Curie 91192 GIF SUR YVETTE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://mics.centralesupelec.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-411575" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-156104" status="VALID">
          <idno type="IdRef">026387433</idno>
          <idno type="ROR">https://ror.org/0321g0743</idno>
          <orgName>Institut Gustave Roussy</orgName>
          <orgName type="acronym">IGR</orgName>
          <desc>
            <address>
              <addrLine>114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.gustaveroussy.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1049541" status="VALID">
          <orgName>Cellules souches hématopoïétiques et développement des hémopathies myéloïdes</orgName>
          <orgName type="acronym">CSHMyelo - U1287 Inserm</orgName>
          <desc>
            <address>
              <addrLine>Université Paris-Saclay, Institut Gustave Roussy,94805, Villejuif.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.gustaveroussy.fr/fr/umr-1287</ref>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
            <relation name="U1287" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300924" status="VALID">
          <idno type="ROR">https://ror.org/0377z4z10</idno>
          <orgName>Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand</orgName>
          <orgName type="acronym">CHU Dijon</orgName>
          <desc>
            <address>
              <addrLine>14 rue Paul Gaffarel - 21079 Dijon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-dijon.fr/fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1096458" status="OLD">
          <idno type="IdRef">15975979X</idno>
          <idno type="RNSR">200716508T</idno>
          <idno type="ROR">https://ror.org/04d70nb60</idno>
          <orgName>Lipides - Nutrition - Cancer [Dijon - U1231]</orgName>
          <orgName type="acronym">LNC</orgName>
          <date type="start">2022-01-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Bourgogne - Faculte de medecine - 7, boulevard Jeanne d'Arc - BP 87900 - 21079 Dijon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://inserm-u866.u-bourgogne.fr/index.php</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300270" type="direct"/>
            <relation name="U1231" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 866" active="#struct-1096329" type="direct"/>
            <relation active="#struct-1042499" type="indirect"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-150180" status="VALID">
          <orgName>Département de biologie et pathologie médicales [Gustave Roussy]</orgName>
          <desc>
            <address>
              <addrLine>Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1057805" status="VALID">
          <orgName>Dynamique moléculaire de la transformation hématopoïétique</orgName>
          <orgName type="acronym">Dynamo</orgName>
          <desc>
            <address>
              <addrLine>Institut Gustave Roussy, Pavillon de recherche 1, 114 rue Edouard-Vaillant, 94805 Villejuif</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.idf.inserm.fr/rubriques/les-laboratoires/structures-de-recherche-paris-11/unites-de-recherche-de-paris-11/val-de-marne-villejuif-gustave-roussy/dynamique-moleculaire-de-la-transformation-hematopoietique</ref>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
            <relation name="U1170" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-411575" status="VALID">
          <idno type="IdRef">184443237</idno>
          <idno type="ROR">https://ror.org/019tcpt25</idno>
          <orgName>CentraleSupélec</orgName>
          <desc>
            <address>
              <addrLine>3, rue Joliot Curie,Plateau de Moulon,91192 GIF-SUR-YVETTE Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centralesupelec.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300270" status="OLD">
          <idno type="IdRef">02819005X</idno>
          <idno type="ISNI">0000000122989313</idno>
          <idno type="ROR">https://ror.org/03k1bsr36</idno>
          <orgName>Université de Bourgogne</orgName>
          <orgName type="acronym">UB</orgName>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bourgogne.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1096329" status="VALID">
          <idno type="IdRef">261024671</idno>
          <idno type="ROR">https://ror.org/03zek0r74</idno>
          <idno type="Wikidata">Q8077943</idno>
          <orgName>Institut Agro Dijon</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://institut-agro-dijon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042499" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042499" status="VALID">
          <idno type="IdRef">260373249</idno>
          <idno type="ROR">https://ror.org/01dkyve95</idno>
          <orgName>Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement</orgName>
          <orgName type="acronym">Institut Agro</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-agro.fr</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-54797" status="VALID">
          <idno type="anr">ANR-18-IBHU-0002</idno>
          <orgName>PRISM</orgName>
          <desc>PRecISion Medicine Institute in oncology</desc>
          <date type="start">2018</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>