<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03986356</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-19T10:52:20+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A Novel Strategy to Enhance Antioxidant Content in Saccharomyces Cerevisiae Based on Oxygen Pressure</title>
            <author role="aut">
              <persName>
                <forename type="first">Na</forename>
                <surname>Cui</surname>
              </persName>
              <idno type="idhal" notation="numeric">1226644</idno>
              <idno type="halauthorid" notation="string">1815820-1226644</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8059-873X</idno>
              <affiliation ref="#struct-1042567"/>
              <affiliation ref="#struct-533302"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Perré</surname>
              </persName>
              <email type="md5">15964ba03b4fba9e6e305826d3245ccd</email>
              <email type="domain">centralesupelec.fr</email>
              <idno type="idhal" notation="string">patrick-perre</idno>
              <idno type="idhal" notation="numeric">6055</idno>
              <idno type="halauthorid" notation="string">983989-6055</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0419-4810</idno>
              <idno type="IDREF">https://www.idref.fr/033107238</idno>
              <affiliation ref="#struct-1042567"/>
              <affiliation ref="#struct-533302"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emilie</forename>
                <surname>Michiels</surname>
              </persName>
              <idno type="halauthorid">1591237-0</idno>
              <affiliation ref="#struct-1042567"/>
              <affiliation ref="#struct-533302"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Victor</forename>
                <surname>Pozzobon</surname>
              </persName>
              <email type="md5">b1f86a4a8323d8da6cd039fdfb24b777</email>
              <email type="domain">centralesupelec.fr</email>
              <idno type="idhal" notation="string">victor-pozzobon</idno>
              <idno type="idhal" notation="numeric">1105285</idno>
              <idno type="halauthorid" notation="string">981653-1105285</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1530-0834</idno>
              <affiliation ref="#struct-1042567"/>
              <affiliation ref="#struct-533302"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Victor</forename>
                <surname>Pozzobon</surname>
              </persName>
              <email type="md5">b1f86a4a8323d8da6cd039fdfb24b777</email>
              <email type="domain">centralesupelec.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-02-13 15:58:56</date>
              <date type="whenModified">2024-02-05 03:17:51</date>
              <date type="whenReleased">2023-03-17 11:57:28</date>
              <date type="whenProduced">2023-02-13</date>
              <date type="whenEndEmbargoed">2023-02-13</date>
              <ref type="file" target="https://centralesupelec.hal.science/hal-03986356v1/document">
                <date notBefore="2023-02-13"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://centralesupelec.hal.science/hal-03986356v1/file/bioengineering-10-00246.pdf" id="file-3986356-3476950">
                <date notBefore="2023-02-13"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="628669">
                <persName>
                  <forename>Victor</forename>
                  <surname>Pozzobon</surname>
                </persName>
                <email type="md5">b1f86a4a8323d8da6cd039fdfb24b777</email>
                <email type="domain">centralesupelec.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03986356</idno>
            <idno type="halUri">https://centralesupelec.hal.science/hal-03986356</idno>
            <idno type="halBibtex">cui:hal-03986356</idno>
            <idno type="halRefHtml">&lt;i&gt;Bioengineering&lt;/i&gt;, 2023, 2 (10), pp.246. &lt;a target="_blank" href="https://dx.doi.org/10.3390/bioengineering10020246"&gt;&amp;#x27E8;10.3390/bioengineering10020246&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Bioengineering, 2023, 2 (10), pp.246. &amp;#x27E8;10.3390/bioengineering10020246&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3986356-3476950"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="LGPM">Laboratoire Génie des Procédés et Matériaux </idno>
            <idno type="stamp" n="CENTRALESUPELEC">Ecole CentraleSupélec</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="CHAIRE-BIOTECH-CS" corresp="LGPM">Chaire de Biotechnologie de CentraleSupélec</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A Novel Strategy to Enhance Antioxidant Content in Saccharomyces Cerevisiae Based on Oxygen Pressure</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Na</forename>
                    <surname>Cui</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1226644</idno>
                  <idno type="halauthorid" notation="string">1815820-1226644</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8059-873X</idno>
                  <affiliation ref="#struct-1042567"/>
                  <affiliation ref="#struct-533302"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Perré</surname>
                  </persName>
                  <email type="md5">15964ba03b4fba9e6e305826d3245ccd</email>
                  <email type="domain">centralesupelec.fr</email>
                  <idno type="idhal" notation="string">patrick-perre</idno>
                  <idno type="idhal" notation="numeric">6055</idno>
                  <idno type="halauthorid" notation="string">983989-6055</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0419-4810</idno>
                  <idno type="IDREF">https://www.idref.fr/033107238</idno>
                  <affiliation ref="#struct-1042567"/>
                  <affiliation ref="#struct-533302"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emilie</forename>
                    <surname>Michiels</surname>
                  </persName>
                  <idno type="halauthorid">1591237-0</idno>
                  <affiliation ref="#struct-1042567"/>
                  <affiliation ref="#struct-533302"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Victor</forename>
                    <surname>Pozzobon</surname>
                  </persName>
                  <email type="md5">b1f86a4a8323d8da6cd039fdfb24b777</email>
                  <email type="domain">centralesupelec.fr</email>
                  <idno type="idhal" notation="string">victor-pozzobon</idno>
                  <idno type="idhal" notation="numeric">1105285</idno>
                  <idno type="halauthorid" notation="string">981653-1105285</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1530-0834</idno>
                  <affiliation ref="#struct-1042567"/>
                  <affiliation ref="#struct-533302"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">130005</idno>
                <idno type="issn">2306-5354</idno>
                <title level="j">Bioengineering</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">2</biblScope>
                  <biblScope unit="issue">10</biblScope>
                  <biblScope unit="pp">246</biblScope>
                  <date type="datePub">2023-02-13</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/bioengineering10020246</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">ferrous ion chelating</term>
                <term xml:lang="en">phenolics</term>
                <term xml:lang="en">antioxidant properties</term>
                <term xml:lang="en">reactive oxygen species</term>
                <term xml:lang="en">flow cytometry</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bio">Life Sciences [q-bio]/Biotechnology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Antioxidant foods represent a potent lever to improve diets while creating value. Yet, their cultivation is often tied to a specific area and climate, limiting availability and increasing market cost. Therefore, microorganism-based antioxidant production emerges as a promising technology to solve these problems. In this view, a novel process was investigated for antioxidant accumulation in yeast culture. S. cerevisiae cells were exposed to various hyperbaric air conditions from 1 to 9 bar (A). Yeast cultures exhibited an increased reactive oxygen species content, which induced oxidative defense expression. After a few hours, reactive oxygen species levels decreased while antioxidant contents remained high, leading to a net increase in antioxidant power. At 6 bar (A), yeast achieved the highest net antioxidant power (phenolics content +48.3 ± 18.6 %, reducing power +120 ± 11.4 %) with an acceptable growth rate (0.27 h −1). Regarding time evolution, a 2 h exposure seems to be the optimum: cells have the lowest reactive oxygen species level while their antioxidant power is increased. From a biotechnological perspective, this finding highlights air pressure as an antioxidant-manipulating stress strategy. Moreover, the proposed process led to a patent that could potentially reduce energy and chemical consumption in such antioxidant accumulation processes.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1042567" status="VALID">
          <idno type="IdRef">152940049</idno>
          <idno type="RNSR">200615287V</idno>
          <orgName>Laboratoire de Génie des Procédés et Matériaux</orgName>
          <orgName type="acronym">LGPM</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>CentraleSupélec - Bâtiment Eiffel - 3 rue Joliot Curie 91190 GIF-SUR-YVETTE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://lgpm.centralesupelec.fr/</ref>
          </desc>
          <listRelation>
            <relation name="EA4038" active="#struct-411575" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-533302" status="VALID">
          <orgName>Centre Européen de Biotechnologies et Bioéconomie</orgName>
          <orgName type="acronym">CEBB</orgName>
          <desc>
            <address>
              <addrLine>3 rue des Rouges Terres 51110 Pomacle</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cebb-innovation.eu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-411575" status="VALID">
          <idno type="IdRef">184443237</idno>
          <idno type="ROR">https://ror.org/019tcpt25</idno>
          <orgName>CentraleSupélec</orgName>
          <desc>
            <address>
              <addrLine>3, rue Joliot Curie,Plateau de Moulon,91192 GIF-SUR-YVETTE Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centralesupelec.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>