In wireless communication, interference between two radio systems may occur when they operate at overlapping frequencies, sharing the same environment at the same time. Such systems coexist if both of them perform correctly with respect to its specifications in the presence of the other. To ensure the coexistence, the Electromagnetic Compatibility (EMC) is used to specify rules within standardization bodies. According to current EMC standards, the radio spectrum has been divided into non-overlapping bands often with exclusive access. However, nowadays there is a proliferation of new digital systems sharing common frequency bands because the spectrum is a limited resource. Many of them are operating in unlicensed bands regulated by The International Telecommunications Union (ITU), for example the 2.45 GHz Industrial, Scientific and Medical (ISM) band. The frequency allocation is also changing with the emergence of digital systems and this is the case for white spaces in the broadcast television (TV) spectrum. To avoid high interference levels, it is necessary to consider some parameters related to signals variations in the time domain, representing more accurately the environment. Some techniques have been proposed in the literature to reduce interference levels but they are applied to specific sharing studies. Hence, we evaluate in this paper the impact of time-domain considerations for radio coexistence. We show that systems sharing the same spectrum can coexist when additional parameters relevant to the time domain are included in the analysis framework. We illustrate these concepts through a specific study case.