This paper presents a systematic tuning approach for Model Predictive Control (MPC) parameters' using an original LabVIEW-implementation of advanced metaheuristics algorithms. Perturbed Particle Swarm Optimization (pPSO), Gravitational Search Algorithm (GSA), Teaching-Learning Based Optimization (TLBO) and Grey Wolf Optimizer (GWO) metaheuristics are proposed to solve the formulated MPC tuning problem under operational constraints. The MPC tuning strategy is done offline for the selection of both prediction and control horizons as well as the weightings matrices. All proposed algorithms are firstly evaluated and validated on a benchmark of standard test functions. The same algorithms were then used to solve the formulated MPC tuning problem for two dynamical systems such as the magnetic levitation system MAGLEV 33-006, and the three-tank DTS200 process. Demonstrative results, in terms of statistical metrics and closed-loop systems responses, are presented and discussed in order to show the effectiveness and superiority of the proposed metaheuristics-tuned approach. The developed CAD interface for the LabVIEW implementation of the proposed metaheuristics is given and freely accessible for extended optimization puposes.