This paper presents a predictive control structure for thermal regulation in buildings. The proposed method exploits the intermittently operating mode of almost all types of buildings. Usually the occupation profile can be known in advance and this fact will be used to reduce the energy consumption without decreasing the thermal comfort during the occupation. For that purpose, the predictive control strategy is first presented for a single zone building then extended to a multizone building example. Two opposite control strategies commonly exists: the decentralized control structure, which does not offer good performances especially when the thermal coupling among adjacent rooms is not negligible, and on the other hand, the centralized control for which the computational demand grows exponentially with the size of the system, being very expensive for large scale buildings. Our solution is based on a distributed approach which takes the advantages of both methods mentioned above. A distributed MPC algorithm with one information exchange per time step is proposed with good control performances and low computational requirements. Simulations and a comparison performance table end the article.